2.2k citations · 4k across the 13 of their papers we have counts for
13 papers
Two blind spots in the demographic inference of human origins from genomic data
Ryan N Gutenkunst
Ancient DNA and new inference methods have transformed the study of human origins, but consensus has not followed. Evidence increasingly indicates that hominin populations were per…
Effect of Dedifferentiation on Time to Mutation Acquisition in Stem Cell-Driven Cancers
Alexandra Jilkine, Ryan N. Gutenkunst
Accumulating evidence suggests that many tumors have a hierarchical organization, with the bulk of the tumor composed of relatively differentiated short-lived progenitor cells that…
A biophysical model of cell adhesion mediated by immunoadhesin drugs and antibodies
Ryan N. Gutenkunst, Daniel Coombs, Toby Star +2
A promising direction in drug development is to exploit the ability of natural killer cells to kill antibody-labeled target cells. Monoclonal antibodies and drugs designed to elici…
Proteins with greater influence on network dynamics evolve more slowly but are not more essential
Ryan N. Gutenkunst
A fundamental question for evolutionary biology is why rates of evolution vary dramatically between proteins. Perhaps surprisingly, it is controversial how much a protein's functio…
Inferring the joint demographic history of multiple populations from multidimensional SNP frequency data
Ryan N. Gutenkunst, Ryan D. Hernandez, Scott H. Williamson +1
Demographic models built from genetic data play important roles in illuminating prehistorical events and serving as null models in genome scans for selection. We introduce an infer…
Sloppiness, robustness, and evolvability in systems biology
Bryan C. Daniels, Yan-Jiun Chen, James P. Sethna +2
The functioning of many biochemical networks is often robust -- remarkably stable under changes in external conditions and internal reaction parameters. Much recent work on robustn…