199 citations · 839 across the 12 of their papers we have counts for
12 papers
Optimization of collective enzyme activity via spatial localization
Alexander Buchner, Filipe Tostevin, Florian Hinzpeter +1
The spatial organization of enzymes often plays a crucial role in the functionality and efficiency of enzymatic pathways. To fully understand the design and operation of enzymatic…
Clustering and optimal arrangement of enzymes in reaction-diffusion systems
Alexander Buchner, Filipe Tostevin, Ulrich Gerland
Enzymes within biochemical pathways are often colocalized, yet the consequences of specific spatial enzyme arrangements remain poorly understood. We study the impact of enzyme arra…
Spatial partitioning improves the reliability of biochemical signaling
Andrew Mugler, Filipe Tostevin, Pieter Rein ten Wolde
Spatial heterogeneity is a hallmark of living systems, even at the molecular scale in individual cells. A key example is the partitioning of membrane-bound proteins via lipid domai…
Signalling noise enhances chemotactic drift of E. coli
Marlo Flores, Thomas S. Shimuzu, Pieter Rein ten Wolde +1
Noise in transduction of chemotactic stimuli to the flagellar motor of E. coli will affect the random run-and-tumble motion of the cell and the ability to perform chemotaxis. Here…
Reliability of frequency- and amplitude-decoding in gene regulation
Filipe Tostevin, Wiet de Ronde, Pieter Rein ten Wolde
In biochemical signaling, information is often encoded in oscillatory signals. However, the advantages of such a coding strategy over an amplitude encoding scheme of constant signa…
Multiplexing Biochemical Signals
Wiet de Ronde, Filipe Tostevin, Pieter Rein ten Wolde
In this paper we show that living cells can multiplex biochemical signals, i.e. transmit multiple signals through the same signaling pathway simultaneously, and yet respond to them…