7 papers
Effects of pyruvate administration on infarct volume and neurological deficits following permanent focal cerebral ischemia in rats
A. Gonzalez-Falcon, E. Candelario-Jalil, M. Garcia-Cabrera +1
Recent experimental evidences indicate that pyruvate, the final metabolite of glycolysis, has a remarkable protective effect against different types of brain injury. The purpose of…
The highly selective cyclooxygenase-2 inhibitor DFU is neuroprotective when given several hours after transient cerebral ischemia in gerbils
E. Candelario-Jalil, D. Alvarez, J. M. Castaneda +4
Several studies suggest that cyclooxygenase-2 contributes to the delayed progression of ischemic brain damage. In this study we examined whether the highly selective cyclooxygenase…
Time course of oxidative damage in different brain regions following transient cerebral ischemia in gerbils
E. Candelario-Jalil, N. H. Mhadu, S. M. Al-Dalain +2
The time course of oxidative damage in different brain regions was investigated in the gerbil model of transient cerebral ischemia. Animals were subjected to both common carotid ar…
Neuroprotective efficacy of nimesulide against hippocampal neuronal damage following transient forebrain ischemia
E. Candelario-Jalil, D. Alvarez, A. Gonzalez-Falcon +5
Cyclooxygenase-2 is involved in the inflammatory component of the ischemic cascade, playing an important role in the delayed progression of the brain damage. The present study eval…
Delayed treatment with nimesulide reduces measures of oxidative stress following global ischemic brain injury in gerbils
E. Candelario-Jalil, D. Alvarez, N. Merino +1
Metabolism of arachidonic acid by cyclooxygenase is one of the primary sources of reactive oxygen species in the ischemic brain. Neuronal overexpression of cyclooxygenase-2 has rec…
Wide therapeutic time window for nimesulide neuroprotection in a model of transient focal cerebral ischemia in the rat
E. Candelario-Jalil, A. Gonzalez-Falcon, M. Garcia-Cabrera +2
Results from several studies indicate that cyclooxygenase-2 (COX-2) is involved in ischemic brain injury. The purpose of this study was to evaluate the neuroprotective effects of t…