most citedOptimization of a Triangular Delaunay Mesh Generator using Reinforcement Learning

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math.OC2026

Identifying Multi-Hit Cancer Drivers Without Massive Parallelization: A CP, MIP, and Column Generation Framework

Rick S. H. Willemsen, Tenindra Abeywickrama, Ramu Anandakrishnan

Cancer is often driven by specific combinations of an estimated two to nine gene mutations, known as multi-hit combinations. Identifying these multi-hit combinations of gene mutati…

math.OC2025

Generating Random Vectors satisfying Linear and Nonlinear Constraints

Rick S. H. Willemsen, Wilco van den Heuvel, Michel van de Velden

We consider the problem of generating n-dimensional vectors with a fixed sum, with the goal of generating a uniform distribution of vectors over a valid region. This means that eac…