3 papers
math.OC2026
Identifying Multi-Hit Cancer Drivers Without Massive Parallelization: A CP, MIP, and Column Generation Framework
Rick S. H. Willemsen, Tenindra Abeywickrama, Ramu Anandakrishnan
Cancer is often driven by specific combinations of an estimated two to nine gene mutations, known as multi-hit combinations. Identifying these multi-hit combinations of gene mutati…
cs.CG2025
Optimization of a Triangular Delaunay Mesh Generator using Reinforcement Learning
Will Thacher, Per-Olof Persson, Yulong Pan
In this work we introduce a triangular Delaunay mesh generator that can be trained using reinforcement learning to maximize a given mesh quality metric. Our mesh generator consists…
math.OC2025
Generating Random Vectors satisfying Linear and Nonlinear Constraints
Rick S. H. Willemsen, Wilco van den Heuvel, Michel van de Velden
We consider the problem of generating n-dimensional vectors with a fixed sum, with the goal of generating a uniform distribution of vectors over a valid region. This means that eac…