3 papers
q-bio.QM2025
Bayesian Non-Negative Matrix Factorization with Correlated Mutation Type Probabilities for Mutational Signatures
Iris Lang, Jenna Landy, Giovanni Parmigiani
Somatic mutations, or alterations in DNA of a somatic cell, are key markers of cancer. In recent years, mutational signature analysis has become a prominent field of study within c…
stat.ME2025
Causal Inference for Latent Outcomes Learned with Factor Models
Jenna M. Landy, Dafne Zorzetto, Roberta De Vito +1
In many fields$\unicode{x2013}$including genomics, epidemiology, natural language processing, social and behavioral sciences, and economics$\unicode{x2013}$it is increasingly impor…
stat.AP2025
Bayesian Probit Multi-Study Non-negative Matrix Factorization for Mutational Signatures
Blake Hansen, Isabella N. Grabski, Giovanni Parmigiani +1
Mutational signatures are patterns of somatic mutations in tumor genomes that provide insights into underlying mutagenic processes and cancer origin. Developing reliable methods fo…