286 citations · 319 across the 10 of their papers we have counts for
3 papers · 1 filter
Probing the Dark Energy in the Functional Protein Universe
Ezequiel A. Galpern, Carlos Bueno, Ignacio E. Sánchez +2
We show how to localize and quantify the functional evolutionary constraints on natural proteins. The method compares the perturbations caused by local sequence variants to the ene…
Frustration In Physiology And Molecular Medicine
R. Gonzalo Parra, Elizabeth A. Komives, Peter G. Wolynes +1
Molecules provide the ultimate language in terms of which physiology and pathology must be understood. Myriads of proteins participate in elaborate networks of interactions and per…
Reassessing the Exon-Foldon correspondence using Frustration Analysis
Ezequiel A. Galpern, Hana Jaafari, Carlos Bueno +2
Protein folding and evolution are intimately linked phenomena. Here, we revisit the concept of exons as potential protein folding modules across 38 abundant and conserved protein f…