286 citations · 319 across the 10 of their papers we have counts for
11 papers
Seismology of Glasses
Zhiyu Cao, Peter G. Wolynes
Aging and relaxation of glasses proceed through localized rearrangements that also generate long-ranged mechanical responses in their surroundings. We develop a theory that treats…
Polyamorphism in Glassy Network Materials
Max Hall-Brown, Peter Guy Wolynes
One dramatic feature of network liquids is the emergence at low temperatures and high pressures of polyamorphism, where multiple distinct liquid phases are accessed in a single mat…
Probing the Dark Energy in the Functional Protein Universe
Ezequiel A. Galpern, Carlos Bueno, Ignacio E. Sánchez +2
We show how to localize and quantify the functional evolutionary constraints on natural proteins. The method compares the perturbations caused by local sequence variants to the ene…
Quantum Simulation of Charge and Exciton Transfer in Multi-mode Models using Engineered Reservoirs
Visal So, Midhuna Duraisamy Suganthi, Mingjian Zhu +7
Quantum simulation offers a route to study open-system molecular dynamics in non-perturbative regimes by programming the interactions among electronic, vibrational, and environment…
Topology of the simplest gene switch
Aleksandra Nelson, Peter Wolynes, Evelyn Tang
Complex gene regulatory networks often display emergent simple behavior. Sometimes this simplicity can be traced to a nearly equivalent energy landscape, but not always. Here, we s…
Frustration In Physiology And Molecular Medicine
R. Gonzalo Parra, Elizabeth A. Komives, Peter G. Wolynes +1
Molecules provide the ultimate language in terms of which physiology and pathology must be understood. Myriads of proteins participate in elaborate networks of interactions and per…
Motorized Chromosome Models of Mitosis
Zhiyu Cao, Chaoqun Du, Zhonghuai Hou +1
During mitosis, near-spherical chromosomes reconfigure into rod-like structures to ensure their accurate segregation to daughter cells. We explore here, the interplay between the n…
Trapped-Ion Quantum Simulation of Electron Transfer Models with Tunable Dissipation
Visal So, Midhuna Duraisamy Suganthi, Abhishek Menon +6
Electron transfer is at the heart of many fundamental physical, chemical, and biochemical processes essential for life. The exact simulation of these reactions is often hindered by…
Reassessing the Exon-Foldon correspondence using Frustration Analysis
Ezequiel A. Galpern, Hana Jaafari, Carlos Bueno +2
Protein folding and evolution are intimately linked phenomena. Here, we revisit the concept of exons as potential protein folding modules across 38 abundant and conserved protein f…
Microscopic Theory of Heterogeneity and Non-Exponential Relaxations in Supercooled Liquids
Xiaoyu Xia, Peter G. Wolynes
Recent experiments and computer simulations show that supercooled liquids around the glass transition temperature are "dynamically heterogeneous" [1]. Such heterogeneity is expecte…
Funnels, Pathways and the Energy Landscape of Protein Folding: A Synthesis
J. D. Bryngelson, J. N. Onuchic, N. D. Socci +1
The understanding, and even the description of protein folding is impeded by the complexity of the process. Much of this complexity can be described and understood by taking a stat…