4 papers
Probing the Dark Energy in the Functional Protein Universe
Ezequiel A. Galpern, Carlos Bueno, Ignacio E. Sánchez +2
We show how to localize and quantify the functional evolutionary constraints on natural proteins. The method compares the perturbations caused by local sequence variants to the ene…
Topology of the simplest gene switch
Aleksandra Nelson, Peter Wolynes, Evelyn Tang
Complex gene regulatory networks often display emergent simple behavior. Sometimes this simplicity can be traced to a nearly equivalent energy landscape, but not always. Here, we s…
Frustration In Physiology And Molecular Medicine
R. Gonzalo Parra, Elizabeth A. Komives, Peter G. Wolynes +1
Molecules provide the ultimate language in terms of which physiology and pathology must be understood. Myriads of proteins participate in elaborate networks of interactions and per…
Motorized Chromosome Models of Mitosis
Zhiyu Cao, Chaoqun Du, Zhonghuai Hou +1
During mitosis, near-spherical chromosomes reconfigure into rod-like structures to ensure their accurate segregation to daughter cells. We explore here, the interplay between the n…