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q-bio.CB2024
A mathematical model for smooth muscle cell phenotype switching in atherosclerotic plaque
Joseph P. Ndenda, Michael G. Watson, Ashish Misra +1
Smooth muscle cells (SMCs) play a fundamental role in the development of atherosclerotic plaques. They ingest lipids in a similar way to monocyte-derived macrophages (MDMs) in the…
q-bio.CB2024
Blood lipoproteins shape the phenotype and lipid content of early atherosclerotic lesion macrophages: a dual-structured mathematical model
Keith L Chambers, Mary R Myerscough, Michael G Watson +1
Macrophages in atherosclerotic lesions exhibit a spectrum of behaviours or phenotypes. The phenotypic distribution of monocyte-derived macrophages (MDMs), its correlation with MDM…