4 papers
A mathematical model for the role of macrophage chemotactic emigration in the early atherosclerotic plaque
Michael G. Watson
Atherosclerotic plaques are fatty, cellular lesions that form in artery walls. The early plaque contains monocyte-derived macrophages, which are recruited to consume locally bound…
A spatially resolved and lipid-structured model for macrophage populations in early human atherosclerotic lesions
Keith L. Chambers, Mary R. Myerscough, Michael G. Watson +1
Atherosclerosis is a chronic inflammatory disease of the artery wall. The early stages of atherosclerosis are driven by interactions between lipids and monocyte-derived-macrophages…
A mathematical model for smooth muscle cell phenotype switching in atherosclerotic plaque
Joseph P. Ndenda, Michael G. Watson, Ashish Misra +1
Smooth muscle cells (SMCs) play a fundamental role in the development of atherosclerotic plaques. They ingest lipids in a similar way to monocyte-derived macrophages (MDMs) in the…
Blood lipoproteins shape the phenotype and lipid content of early atherosclerotic lesion macrophages: a dual-structured mathematical model
Keith L Chambers, Mary R Myerscough, Michael G Watson +1
Macrophages in atherosclerotic lesions exhibit a spectrum of behaviours or phenotypes. The phenotypic distribution of monocyte-derived macrophages (MDMs), its correlation with MDM…