3 papers
math.OC2025
Highly Efficient Optimal Control for Lyophilization via Simulation of Discrete/Continuous Mixed-index Differential-algebraic Equations
Prakitr Srisuma, Richard D. Braatz
This article presents a highly efficient optimal control algorithm and policies for lyophilization (also known as freeze drying). The optimal solutions and control policies are der…
cs.CE2025
Probabilistically Robust Uncertainty Analysis and Optimal Control of Continuous Lyophilization via Polynomial Chaos Theory
Prakitr Srisuma, George Barbastathis, Richard D. Braatz
Lyophilization, aka freeze drying, is a process commonly used to increase the stability of various drug products in biotherapeutics manufacturing, e.g., mRNA vaccines, allowing for…
eess.SY2024
Simulation-based Approach for Fast Optimal Control of a Stefan Problem with Application to Cell Therapy
Prakitr Srisuma, George Barbastathis, Richard D. Braatz
This article describes a new, efficient way of finding control and state trajectories in optimal control problems by reformulation as a system of differential-algebraic equations (…