17 citations · 32 across the 7 of their papers we have counts for
7 papers
Integrated Population Balance and Multiphysics Modeling for Predicting Undesired Agglomeration in Small Molecule Manufacturing
Prakitr Srisuma, Peter Hou, Shashank Venkat Muddu +3
Agitated filter dryers (AFDs) are a crucial unit operation in small molecule manufacturing that enables simultaneous filtration, washing, and drying of active pharmaceutical ingred…
Highly Efficient Optimal Control for Lyophilization via Simulation of Discrete/Continuous Mixed-index Differential-algebraic Equations
Prakitr Srisuma, Richard D. Braatz
This article presents a highly efficient optimal control algorithm and policies for lyophilization (also known as freeze drying). The optimal solutions and control policies are der…
Probabilistically Robust Uncertainty Analysis and Optimal Control of Continuous Lyophilization via Polynomial Chaos Theory
Prakitr Srisuma, George Barbastathis, Richard D. Braatz
Lyophilization, aka freeze drying, is a process commonly used to increase the stability of various drug products in biotherapeutics manufacturing, e.g., mRNA vaccines, allowing for…
Simulation-based Approach for Fast Optimal Control of a Stefan Problem with Application to Cell Therapy
Prakitr Srisuma, George Barbastathis, Richard D. Braatz
This article describes a new, efficient way of finding control and state trajectories in optimal control problems by reformulation as a system of differential-algebraic equations (…
Mechanistic Modeling of Continuous Lyophilization for Biopharmaceutical Manufacturing
Prakitr Srisuma, Gang Chen, Richard D. Braatz
Lyophilization (aka freeze drying) is a typical process in pharmaceutical manufacturing used for improving the stability of various drug products, including its recent applications…
Real-time Estimation of Bound Water Concentration during Lyophilization with Temperature-based State Observers
Prakitr Srisuma, George Barbastathis, Richard Braatz
Lyophilization (aka freeze drying) has been shown to provide long-term stability for many crucial biotherapeutics, e.g., mRNA vaccines for COVID-19, allowing for higher storage tem…
Mechanistic Modeling and Analysis of Thermal Radiation in Conventional, Microwave-assisted, and Hybrid Freeze Drying for Biopharmaceutical Manufacturing
Prakitr Srisuma, George Barbastathis, Richard D. Braatz
In freeze drying, thermal radiation has a significant effect on the drying process of vials located near the corner and edge of the trays, resulting in non-uniformity of the produc…