170 citations · 2.2k across the 59 of their papers we have counts for
5 papers · 1 filter
Search and localization dynamics of the CRISPR/Cas9 system
Qiao Lu, Deepak Bhat, Darya Stepanenko +1
The CRISPR/Cas9 system acts as the prokaryotic immune system and has important applications in gene editing. The protein Cas9 is one of its crucial components. The role of Cas9 is…
Error-speed correlations in biopolymer synthesis
Davide Chiuchiú, Yuhai Tu, Simone Pigolotti
Synthesis of biopolymers such as DNA, RNA, and proteins are biophysical processes aided by enzymes. Performance of these enzymes is usually characterized in terms of their average…
Protocols for copying and proofreading in template-assisted polymerization
Simone Pigolotti, Pablo Sartori
We discuss how information encoded in a template polymer can be stochastically copied into a copy polymer. We consider four different stochastic copy protocols of increasing comple…
Thermodynamics of Error Correction
Pablo Sartori, Simone Pigolotti
Information processing at the molecular scale is limited by thermal fluctuations. This can cause undesired consequences in copying information since thermal noise can lead to error…
Kinetic vs. energetic discrimination in biological copying
Pablo Sartori, Simone Pigolotti
We study stochastic copying schemes in which discrimination between a right and a wrong match is achieved via different kinetic barriers or different binding energies of the two ma…