5 citations · 5 across the 2 of their papers we have counts for
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stat.ME2026
A staggered seamless dose-optimization design for co-developing monotherapy and combination therapy
Masahiro Kojima, Kentaro Takeda, Ying Yuan
Contemporary oncology drug development increasingly requires efficient dose-optimization strategies that evaluate monotherapy (Mono) and combination therapy (Combo) while balancing…
stat.ME2024★ 5 cited
ROMI: A Randomized Two-Stage Basket Trial Design to Optimize Doses for Multiple Indications
Shuqi Wang, Peter F. Thall, Kentaro Takeda +1
Optimizing doses for multiple indications is challenging. The pooled approach of finding a single optimal biological dose (OBD) for all indications ignores that dose-response or do…