4 papers · 1 filter
Synthesis Cost-Optimal Targeted Mutant Protein Libraries
Dimitris Papamichail, Madeline Febinger, Shm Almeda +1
Protein variant libraries produced by site-directed mutagenesis are a useful tool utilized by protein engineers to explore variants with potentially improved properties, such as ac…
Most Compact Parsimonious Trees
Dimitris Papamichail, Angela Huang, Andrew Miller +3
Construction of phylogenetic trees has traditionally focused on binary trees where all species appear on leaves, a problem for which numerous efficient solutions have been develope…
Codon Context Optimization in Synthetic Gene Design
Dimitris Papamichail, Hongmei Liu, Vitor Machado +3
Advances in de novo synthesis of DNA and computational gene design methods make possible the customization of genes by direct manipulation of features such as codon bias and mRNA s…
Static Level Ancestors in Practice
Matthew Mabrey, Thomas Caputi, Georgios Papamichail +1
Given a rooted tree T, the level ancestor problem aims to answer queries of the form LA(v, d), which identify the level d ancestor of a node v in the tree. Several algorithms of va…