134 citations · 326 across the 6 of their papers we have counts for
6 papers
Evolution of new regulatory functions on biophysically realistic fitness landscapes
Tamar Friedlander, Roshan Prizak, Nicholas H. Barton +1
Regulatory networks consist of interacting molecules with a high degree of mutual chemical specificity. How can these molecules evolve when their function depends on maintenance of…
Intrinsic limits to gene regulation by global crosstalk
Tamar Friedlander, Roshan Prizak, Călin C. Guet +2
Gene regulation relies on the specificity of transcription factor (TF) - DNA interactions. In equilibrium, limited specificity may lead to crosstalk: a regulatory state in which a…
Evolution of bow-tie architectures in biology
Tamar Friedlander, Avraham E. Mayo, Tsvi Tlusty +1
Bow-tie or hourglass structure is a common architectural feature found in biological and technological networks. A bow-tie in a multi-layered structure occurs when intermediate lay…
Mutation Rules and the Evolution of Sparseness and Modularity in Biological Systems
Tamar Friedlander, Avraham E. Mayo, Tsvi Tlusty +1
Biological systems exhibit two structural features on many levels of organization: sparseness, in which only a small fraction of possible interactions between components actually o…
Adaptive response and enlargement of dynamic range
Tamar Friedlander, Naama Brenner
Many membrane channels and receptors exhibit adaptive, or desensitized, response to a strong sustained input stimulus, often supported by protein activity-dependent inactivation. A…
From cellular properties to population asymptotics in the Population Balance Equation
Tamar Friedlander, Naama Brenner
Proliferating cell populations at steady state growth often exhibit broad protein distributions with exponential tails. The sources of this variation and its universality are of mu…