6 papers · 1 filter
Dual mechanism of Anti-Seizure Medications in controlling seizure activity
Guillermo M. Besne, Emmanuel Molefi, Sarah J. Gascoigne +12
Background: Anti-seizure medications (ASMs) can reduce seizure duration, but their precise modes of action are unclear. Specifically, it is unknown whether ASMs shorten seizures by…
More variable circadian rhythms in epilepsy captured by long-term heart rate recordings from wearable sensors
Billy C. Smith, Christopher Thornton, Rachel E. Stirling +7
Objective: The circadian rhythm synchronizes physiological and behavioural patterns with the 24-hour light-dark cycle. Disruption to the circadian rhythm is linked to various healt…
Comparing Methodological Variations in Seizure Onset Localisation Algorithms using intracranial EEG
Sarah J. Gascoigne, Manel Vila-Vidal, Nathan Evans +9
During clinical treatment for epilepsy, the area of the brain thought to be responsible for pathological activity is identified. This identification is typically performed through…
Unsupervised Machine Learning Identifies Latent Ultradian States in Multi-Modal Wearable Sensor Signals
Christopher Thornton, Billy C. Smith, Guillermo M. Besne +2
Wearable sensors such as smartwatches have become ubiquitous in recent years, allowing the easy and continual measurement of physiological parameters such as heart rate, physical a…
Anti-seizure medication tapering correlates with daytime delta band power reduction in the cortex
Guillermo M. Besne, Nathan Evans, Mariella Panagiotopoulou +11
Anti-seizure medications (ASMs) are the primary treatment for epilepsy, yet medication tapering effects have not been investigated in a dose, region, and time-dependent manner, des…
Diminished circadian and ultradian rhythms of human brain activity in pathological tissue in vivo
Christopher Thornton, Mariella Panagiotopoulou, Fahmida A Chowdhury +10
Chronobiological rhythms, such as the circadian rhythm, have long been linked to neurological disorders, but it is currently unknown how pathological processes affect the expressio…