4 papers
Multimodal Modeling of Ultradian Rhythms Using the Hankel Alternative View of Koopman (HAVOK) Analysis
Emmanuel Molefi, Billy C. Smith, Christopher Thornton +2
Ultradian rhythms - quasi-rhythmic fluctuations in behavior and physiology with periods shorter than 24 hours - are observed across various organisms, including humans. Despite the…
Dual mechanism of Anti-Seizure Medications in controlling seizure activity
Guillermo M. Besne, Emmanuel Molefi, Sarah J. Gascoigne +12
Background: Anti-seizure medications (ASMs) can reduce seizure duration, but their precise modes of action are unclear. Specifically, it is unknown whether ASMs shorten seizures by…
More variable circadian rhythms in epilepsy captured by long-term heart rate recordings from wearable sensors
Billy C. Smith, Christopher Thornton, Rachel E. Stirling +7
Objective: The circadian rhythm synchronizes physiological and behavioural patterns with the 24-hour light-dark cycle. Disruption to the circadian rhythm is linked to various healt…
Unsupervised Machine Learning Identifies Latent Ultradian States in Multi-Modal Wearable Sensor Signals
Christopher Thornton, Billy C. Smith, Guillermo M. Besne +2
Wearable sensors such as smartwatches have become ubiquitous in recent years, allowing the easy and continual measurement of physiological parameters such as heart rate, physical a…