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20232026
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physics.med-ph2025

AI in Proton Therapy Treatment Planning: A Review

Yuzhen Ding, Hongying Feng, Martin Bues +12

Purpose: Proton therapy provides superior dose conformity compared to photon therapy, but its treatment planning is challenged by sensitivity to anatomical changes, setup/range unc…

physics.med-ph2025

Diffusion Transformer-based Universal Dose Denoising for Pencil Beam Scanning Proton Therapy

Yuzhen Ding, Jason Holmes, Hongying Feng +13

Purpose: Intensity-modulated proton therapy (IMPT) offers precise tumor coverage while sparing organs at risk (OARs) in head and neck (H&N) cancer. However, its sensitivity to anat…

physics.med-ph2025

Fine-Tuning Open-Source Large Language Models to Improve Their Performance on Radiation Oncology Tasks: A Feasibility Study to Investigate Their Potential Clinical Applications in Radiation Oncology

Peilong Wang, Zhengliang Liu, Yiwei Li +12

Background: The radiation oncology clinical practice involves many steps relying on the dynamic interplay of abundant text data. Large language models have displayed remarkable cap…

physics.med-ph2025

Evaluating The Performance of Using Large Language Models to Automate Summarization of CT Simulation Orders in Radiation Oncology

Meiyun Cao, Shaw Hu, Jason Sharp +10

Purpose: This study aims to use a large language model (LLM) to automate the generation of summaries from the CT simulation orders and evaluate its performance. Materials and Metho…

physics.med-ph2024

Robust Optimization for Spot Scanning Proton Therapy based on Dose-Linear Energy Transfer (LET) Volume Constraints

Jingyuan Chen, Yunze Yang, Hongying Feng +8

Purpose: Historically, spot scanning proton therapy (SSPT) treatment planning utilizes dose volume constraints and linear-energy-transfer (LET) volume constraints separately to bal…

physics.med-ph2023

Noisy probing dose facilitated dose prediction for pencil beam scanning proton therapy: physics enhances generalizability

Lian Zhang, Jason M. Holmes, Zhengliang Liu +11

Purpose: Prior AI-based dose prediction studies in photon and proton therapy often neglect underlying physics, limiting their generalizability to handle outlier clinical cases, esp…