activity
20232026
most citedAccurate Patient Alignment without Unnecessary Imaging Dose via Synthesizing Patient-specific 3D CT Images from 2D kV Images

6 citations · 11 across the 10 of their papers we have counts for

collaborators

13 papers

eess.IV2026

Personalising Deformable Image Registration with Clinical Context and Deformation History for Adaptive Radiotherapy

Caiwen Jiang, Songlin Zhao, Yuzhen Ding +23

Adaptive radiotherapy must account for anatomical changes during treatment, but doing so depends on reliably mapping targets, organs at risk and dose across serial images. Existing…

cs.CL2026

The Daily Dose: Workflow-Integrated Large Language Model Automation for Clinical Summarization and Trial Identification in Radiation Oncology

Jason Holmes, Federico Mastroleo, Mariana Borras-Osorio +17

Objective: To describe the design and early clinical evaluation of The Daily Dose (TDD), an LLM-driven, automated clinical summarization and clinical-trial identification system in…

cs.CV2026

A Multimodal Clinically Informed Coarse-to-Fine Framework for Longitudinal CT Registration in Proton Therapy

Caiwen Jiang, Yuzhen Ding, Mi Jia +14

Proton therapy offers superior organ-at-risk sparing but is highly sensitive to anatomical changes, making accurate deformable image registration (DIR) across longitudinal CT scans…

physics.med-ph2025

AI in Proton Therapy Treatment Planning: A Review

Yuzhen Ding, Hongying Feng, Martin Bues +12

Purpose: Proton therapy provides superior dose conformity compared to photon therapy, but its treatment planning is challenged by sensitivity to anatomical changes, setup/range unc…

cs.AI2025

An Automated Retrieval-Augmented Generation LLaMA-4 109B-based System for Evaluating Radiotherapy Treatment Plans

Junjie Cui, Peilong Wang, Jason Holmes +15

Purpose: To develop a retrieval-augmented generation (RAG) system powered by LLaMA-4 109B for automated, protocol-aware, and interpretable evaluation of radiotherapy treatment plan…

cs.AI2025★ 1 cited

RadOnc-GPT: An Autonomous LLM Agent for Real-Time Patient Outcomes Labeling at Scale

Jason Holmes, Yuexing Hao, Mariana Borras-Osorio +22

Manual labeling limits the scale, accuracy, and timeliness of patient outcomes research in radiation oncology. We present RadOnc-GPT, an autonomous large language model (LLM)-based…

physics.med-ph2025

Diffusion Transformer-based Universal Dose Denoising for Pencil Beam Scanning Proton Therapy

Yuzhen Ding, Jason Holmes, Hongying Feng +13

Purpose: Intensity-modulated proton therapy (IMPT) offers precise tumor coverage while sparing organs at risk (OARs) in head and neck (H&N) cancer. However, its sensitivity to anat…

physics.med-ph2025

Fine-Tuning Open-Source Large Language Models to Improve Their Performance on Radiation Oncology Tasks: A Feasibility Study to Investigate Their Potential Clinical Applications in Radiation Oncology

Peilong Wang, Zhengliang Liu, Yiwei Li +12

Background: The radiation oncology clinical practice involves many steps relying on the dynamic interplay of abundant text data. Large language models have displayed remarkable cap…

physics.med-ph2025★ 4 cited

Evaluating The Performance of Using Large Language Models to Automate Summarization of CT Simulation Orders in Radiation Oncology

Meiyun Cao, Shaw Hu, Jason Sharp +10

Purpose: This study aims to use a large language model (LLM) to automate the generation of summaries from the CT simulation orders and evaluate its performance. Materials and Metho…

physics.med-ph2024

Robust Optimization for Spot Scanning Proton Therapy based on Dose-Linear Energy Transfer (LET) Volume Constraints

Jingyuan Chen, Yunze Yang, Hongying Feng +8

Purpose: Historically, spot scanning proton therapy (SSPT) treatment planning utilizes dose volume constraints and linear-energy-transfer (LET) volume constraints separately to bal…

eess.SP2024★ 6 cited

Accurate Patient Alignment without Unnecessary Imaging Dose via Synthesizing Patient-specific 3D CT Images from 2D kV Images

Yuzhen Ding, Jason M. Holmes, Hongying Feng +8

In radiotherapy, 2D orthogonally projected kV images are used for patient alignment when 3D-on-board imaging(OBI) unavailable. But tumor visibility is constrained due to the projec…

physics.med-ph2023

Noisy probing dose facilitated dose prediction for pencil beam scanning proton therapy: physics enhances generalizability

Lian Zhang, Jason M. Holmes, Zhengliang Liu +11

Purpose: Prior AI-based dose prediction studies in photon and proton therapy often neglect underlying physics, limiting their generalizability to handle outlier clinical cases, esp…

physics.med-ph2023

Modelling small block aperture in an in-house developed GPU-accelerated Monte Carlo-based dose engine for pencil beam scanning proton therapy

Hongying Feng, Jason M. Holmes, Sujay A. Vora +8

Purpose: To enhance an in-house graphic-processing-unit (GPU) accelerated virtual particle (VP)-based Monte Carlo (MC) proton dose engine (VPMC) to model aperture blocks in both do…