75 citations · 75 across the 4 of their papers we have counts for
Showing q-bio.TOShow all
2 papers · 1 filter
q-bio.TO2006★ 75 cited
Simulating Brain Tumor Heterogeneity with a Multiscale Agent-Based Model: Linking Molecular Signatures, Phenotypes and Expansion Rate
Le Zhang, Costas G. Strouthos, Zhihui Wang +1
We have extended our previously developed 3D multi-scale agent-based brain tumor model to simulate cancer heterogeneity and to analyze its impact across the scales of interest. Whi…
q-bio.TO2006
Development of a Three-Dimensional Multiscale Agent-Based Tumor Model: Simulating Gene-Protein Interaction Profiles, Cell Phenotypes & Multicellular Patterns in Brain Cancer
Le Zhang, Chaitanya A. Athale, Thomas S. Deisboeck
Experimental evidence suggests that epidermal growth factor receptor (EGFR)-mediated activation of the signaling protein phospholipase C gamma plays a critical role in a cancer cel…