75 citations · 75 across the 4 of their papers we have counts for
4 papers
Cancer Cell Motility: Optimizing Spatial Search Strategies
L. Leon Chen, Le Zhang, Jeongah Yoon +1
Aberrantly regulated cell motility is a hallmark of cancer cells. A hybrid agent-based model has been developed to investigate the synergistic and antagonistic cell motility-impact…
Multi-Scale, Multi-Resolution Brain Cancer Modeling
Le Zhang, L. Leon Chen, Thomas S. Deisboeck
In advancing discrete-based computational cancer models towards clinical applications, one faces the dilemma of how to deal with an ever growing amount of biomedical data that ough…
Simulating Brain Tumor Heterogeneity with a Multiscale Agent-Based Model: Linking Molecular Signatures, Phenotypes and Expansion Rate
Le Zhang, Costas G. Strouthos, Zhihui Wang +1
We have extended our previously developed 3D multi-scale agent-based brain tumor model to simulate cancer heterogeneity and to analyze its impact across the scales of interest. Whi…
Development of a Three-Dimensional Multiscale Agent-Based Tumor Model: Simulating Gene-Protein Interaction Profiles, Cell Phenotypes & Multicellular Patterns in Brain Cancer
Le Zhang, Chaitanya A. Athale, Thomas S. Deisboeck
Experimental evidence suggests that epidermal growth factor receptor (EGFR)-mediated activation of the signaling protein phospholipase C gamma plays a critical role in a cancer cel…