50 citations · 110 across the 6 of their papers we have counts for
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Helicase processivity and not the unwinding velocity exhibits universal increase with force
David L. Pincus, Shaon Chakrabarti, D. Thirumalai
Helicases, involved in a number of cellular functions, are motors that translocate along singlestranded nucleic acid and couple the motion to unwinding double-strands of a duplex n…
Force-Induced Unzipping Transitions in an Athermal Crowded Environment
David L. Pincus, D. Thirumalai
Using theoretical arguments and extensive Monte Carlo (MC) simulations of a coarse-grained three-dimensional off-lattice model of a β-hairpin, we demonstrate that the equilibrium c…
Crowding effects on the mechanical stability and unfolding pathways of Ubiquitin
David L. Pincus, D. Thirumalai
The interior of cells is crowded thus making it important to assess the effects of macromolecules on the folding of proteins. Using the Self-Organized Polymer (SOP) model, which is…
Minimal models for proteins and RNA: From folding to function
D. L. Pincus, S. S. Cho, C. Hyeon +1
We present a panoramic view of the utility of coarse-grained (CG) models to study folding and functions of proteins and RNA. Drawing largely on the methods developed in our group o…