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Watching Single Unmodified Enzymes at Work
Cuifeng Ying, Edona Karakaci, Esteban Bermudez-Urena +10
Many proteins undergo conformational changes during their activity. A full understanding of the function of these proteins can only be obtained if different conformations and trans…
Theory for the Acoustic Raman Modes of Proteins
Timothy DeWolf, Reuven Gordon
We present a theoretical analysis that associates the resonances of extraordinary acoustic Raman (EAR) spectroscopy [Wheaton et al., Nat Photon 9, 68 (2015)] with the collective mo…
Dynamic Variation in Protein-Small Molecule Interaction Observed by Double-Nanohole Optical Trapping
Ahmed Al Balushi, Reuven Gordon
The interaction of proteins with small molecules is fundamental to their function in living organisms and it is widely studied in drug development. Here we compare optical trapping…
Nanoplasmonic Tweezers Visualize Protein p53 Suppressing Unzipping of Single DNA-Hairpins
Abhay Kotnala, Reuven Gordon
Here we report on the use of double-nanohole (DNH) optical tweezers as a label-free and free-solution single-molecule probe for protein-DNA interactions. Using this approach, we de…