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stat.ME2025
Resilience Measures for the Surrogate Paradox
Emily Hsiao, Lu Tian, Layla Parast
Surrogate markers are often used in clinical trials to evaluate treatment effects when primary outcomes are costly, invasive, or take a long time to observe. However, reliance on s…
stat.ME2025
Assessing Surrogate Heterogeneity in Real World Data Using Meta-Learners
Rebecca Knowlton, Layla Parast
Surrogate markers are most commonly studied within the context of randomized clinical trials. However, the need for alternative outcomes extends beyond these settings and may be mo…
stat.ME2025
Efficient Testing Using Surrogate Information
Rebecca Knowlton, Layla Parast
In modern clinical trials, there is immense pressure to use surrogate markers in place of an expensive or long-term primary outcome to make more timely decisions about treatment ef…