4 papers
Meta-analysis and Topological Perturbation in Interactomic Network for Anti-opioid Addiction Drug Repurposing
Chunhuan Zhang, Sean Cottrell, Benjamin Jones +5
The ongoing opioid crisis highlights the urgent need for novel therapeutic strategies that can be rapidly deployed. This study presents a novel approach to identify potential repur…
Machine learning predictions from unpredictable chaos
Jian Jiang, Long Chen, Lu ke +7
Chaos is omnipresent in nature, and its understanding provides enormous social and economic benefits. However, the unpredictability of chaotic systems is a textbook concept due to…
Proteomic Learning of Gamma-Aminobutyric Acid (GABA) Receptor-Mediated Anesthesia
Jian Jiang, Long Chen, Yueying Zhu +5
Anesthetics are crucial in surgical procedures and therapeutic interventions, but they come with side effects and varying levels of effectiveness, calling for novel anesthetic agen…
TIDAL: Topology-Inferred Drug Addiction Learning
Zhu Zailiang, Dou Bozheng, Cao Yukang +8
Drug addiction or drug overdose is a global public health crisis, and the design of anti-addiction drugs remains a major challenge due to intricate mechanisms. Since experimental d…