14 citations · 32 across the 7 of their papers we have counts for
4 papers · 1 filter
High Performance Multiple Sequence Alignment Algorithms for Comparison of Microbial Genomes
Manal Helal, Hossam El-Gindy, Bruno Gaeta +1
Advances in gene sequencing have enabled in silico analyses of microbial genomes and have led to the revision of concepts of microbial taxonomy and evolution. We explore deficienci…
Defining Reference Sequences for Nocardia Species by Similarity and Clustering Analyses of 16S rRNA Gene Sequence Data
Manal Helal, Fanrong Kong, Sharon C. A. Chen +3
The intra- and inter-species genetic diversity of bacteria and the absence of 'reference', or the most representative, sequences of individual species present a significant challen…
Linear normalised hash function for clustering gene sequences and identifying reference sequences from multiple sequence alignments
Manal Helal, Fanrong Kong, Sharon C-A Chen +4
The aim of this study was to develop a method that would identify the cluster centroids and the optimal number of clusters for a given sensitivity level and could work equally well…
Dynamic Programming Algorithms for Discovery of Antibiotic Resistance in Microbial Genomes
Manal Helal, Vitali Sintchenko
The translation of comparative genomics into clinical decision support tools often depends on the quality of sequence alignments. However, currently used methods of multiple sequen…