most citedGene Expression Noise Facilitates Adaptation and Drug Resistance Independently of Mutation

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physics.comp-ph2011★ 13 cited

An Algorithm for the Stochastic Simulation of Gene Expression and Heterogeneous Population Dynamics

Daniel A. Charlebois, Jukka Intosalmi, Dawn Fraser +1

We present an algorithm for the stochastic simulation of gene expression and heterogeneous population dynamics. The algorithm combines an exact method to simulate molecular-level f…