93 citations · 116 across the 4 of their papers we have counts for
4 papers
Lattice-based simulation of the effects of nutrient concentration and magnetic field exposure on yeast colony growth and morphology
Rebekah Hall, Daniel A. Charlebois
Yeasts exist in communities that expand over space and time to form complex structures and patterns. We developed a computational lattice-based framework to perform spatial-tempora…
Does Non-Genetic Heterogeneity Facilitate the Development of Genetic Drug Resistance?
Kevin S. Farquhar, Samira Rasouli Koohi, Daniel A. Charlebois
Non-genetic forms of antimicrobial drug resistance can result from cell-to-cell variability that is not encoded in the genetic material. Data from recent studies also suggest that…
Gene Expression Noise Facilitates Adaptation and Drug Resistance Independently of Mutation
Daniel A. Charlebois, Nezar Abdennur, Mads Kaern
We show that the effect of stress on the reproductive fitness of noisy cell populations can be modelled as first-passage time problem, and demonstrate that even relatively short-li…
An Algorithm for the Stochastic Simulation of Gene Expression and Heterogeneous Population Dynamics
Daniel A. Charlebois, Jukka Intosalmi, Dawn Fraser +1
We present an algorithm for the stochastic simulation of gene expression and heterogeneous population dynamics. The algorithm combines an exact method to simulate molecular-level f…