36 citations · 38 across the 11 of their papers we have counts for
8 papers · 1 filter
Likelihood-Ratio E-Value Monitoring for Benchmark-Based Decisions in Early-Phase Oncology Trials
Masahiro Kojima
Early-phase oncology trials often require protocol-ready interim rules for deciding whether an experimental regimen shows sufficient activity relative to prespecified clinical benc…
Dynamic Borrowing Method for Historical Information Using a Frequentist Approach for Hybrid Control Design
Masahiro Kojima
Information borrowing from historical data is gaining attention in clinical trials of rare and pediatric diseases, where statistical power may be insufficient for confirmation of e…
Adaptive Cohort Size Determination Method for Bayesian Optimal Interval Phase I/II Design to Shorten Clinical Trial Duration
Masahiro Kojima
Recently, the strategy for dose optimization in oncology has shifted to conduct Phase 2 randomized controlled trials with multiple doses. Optimal biologic dose selection from Phase…
Variable Selection using Inverse Survival Probability Weighting
Masahiro Kojima
In this paper, we propose two variable selection methods for adjusting the censoring information for survival times, such as the restricted mean survival time. To adjust for the in…
Comparison of Baseline Covariate Adjustment Methods for Restricted Mean Survival Time
Keisuke Hanada, Junji Moriya, Masahiro Kojima
The restricted mean survival time is a clinically easy-to-interpret measure that does not require any assumption of proportional hazards. We focus on two ways to directly model the…
Data-Dependent Early Completion of Dose Finding Trials for Drug-Combination
Masahiro Kojima
We propose a data-dependent early completion of dose finding trials for drug-combination. The early completion is determined when a beta-binomial probability for dose retainment wi…
Adaptive design for identifying maximum tolerated dose early to accelerate dose-finding trial
Masahiro Kojima
Purpose: The early identification of maximum tolerated dose (MTD) in phase I trial leads to faster progression to a phase II trial or an expansion cohort to confirm efficacy. Metho…
Adaptive Contrast Test for Dose-Response Studies and Modeling
Masahiro Kojima
We propose a powerful adaptive contrast test with ordinal constraint contrast coefficients determined by observed responses. The adaptive contrast test can perform using easily cal…