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physics.bio-ph2022★ 1 cited
Adjusting the range of cell-cell communication enables fine-tuning of cell fate patterns from checkerboard to engulfing
Simon Schardt, Sabine C. Fischer
During development, spatio-temporal patterns ranging from checkerboard to engulfing occur with precise proportions of the respective cell fates. Key developmental regulators are in…
physics.bio-ph2021★ 1 cited
NANOG/GATA6 Interactions Revisited: A Statistical Mechanics Approach towards Cell Fate Decisions
Simon Schardt, Sabine C. Fischer
In preimplantation mammalian embryos, the second cell fate decision introduces spatial patterns of embryonic and extra-embryonic precursor cells. The transcription factors NANOG an…