4 papers · 1 filter
Principles in harmony: Closed testing meets the partitioning principle for computational efficiency
Werner Brannath, Liane Kluge
We explore and utilize the algorithmic relationship between the closed testing principle for multiple tests with family-wise error rate (FWER) control and the partitioning principl…
Informative Simultaneous Confidence Intervals for Graphical Group Sequential Test Procedures
Liane Kluge, Werner Brannath
Test procedures for multiple hypotheses in a group sequential clinical trial that control the family-wise error rate are considered. Several graphical group sequential tests sugges…
Adaptive Designs in Fast-Track Registration Processes for Digital Health Applications
Liane Kluge, Werner Brannath
Fast-track procedures play an important role in the context of conditional registration of medical devices, such as listing processes for digital health applications. They offer th…
Informative Simultaneous Confidence Intervals for Graphical Test Procedures
Werner Brannath, Liane Kluge, Martin Scharpenberg
Simultaneous confidence intervals (SCIs) that are compatible with a given closed test procedure are often non-informative. More precisely, for a one-sided null hypothesis, the boun…