122 citations · 222 across the 3 of their papers we have counts for
4 papers
Biophysical inference of epistasis and the effects of mutations on protein stability and function
Jakub Otwinowski
Understanding the relationship between protein sequence, function, and stability is a fundamental problem in biology. While high-throughput methods have produced large numbers of s…
Host-pathogen coevolution and the emergence of broadly neutralizing antibodies in chronic infections
Armita Nourmohammad, Jakub Otwinowski, Joshua B. Plotkin
The vertebrate adaptive immune system provides a flexible and diverse set of molecules to neutralize pathogens. Yet, viruses such as HIV can cause chronic infections by evolving as…
The diversity of evolutionary dynamics on epistatic versus non-epistatic fitness landscapes
David M. McCandlish, Jakub Otwinowski, Joshua B. Plotkin
The class of epistatic fitness landscapes is much more diverse than the class of non-epistatic landscapes, and so it stands to reason that there exist dynamical phenomena that can…
Inferring fitness landscapes by regression produces biased estimates of epistasis
Jakub Otwinowski, Joshua B. Plotkin
The genotype-fitness map plays a fundamental role in shaping the dynamics of evolution. However, it is difficult to directly measure a fitness landscape in practice, because the nu…