3 papers
math.ST2021
Mixture models for spherical data with applications to protein bioinformatics
Kanti V. Mardia, Stuart Barber, Philippa M. Burdett +2
Finite mixture models are fitted to spherical data. Kent distributions are used for the components of the mixture because they allow considerable flexibility. Previous work on such…
q-bio.BM2021
Persistent topology of protein space
W. Hamilton, J. E. Borgert, T. Hamelryck +1
Protein fold classification is a classic problem in structural biology and bioinformatics. We approach this problem using persistent homology. In particular, we use alpha shape fil…
stat.ME2018
Toroidal diffusions and protein structure evolution
Eduardo García-Portugués, Michael Golden, Michael Sørensen +3
This chapter shows how toroidal diffusions are convenient methodological tools for modelling protein evolution in a probabilistic framework. The chapter addresses the construction…