11 citations · 11 across the 2 of their papers we have counts for
4 papers · 1 filter
An individual-based model to explore the impact of psychological stress on immune infiltration into tumour spheroids
Emma Leschiera, Gheed Al-Hity, Melanie S. Flint +4
In recent in vitro experiments on co-culture between breast tumour spheroids and activated immune cells, it was observed that the introduction of the stress hormone cortisol result…
Evolutionary dynamics of glucose-deprived cancer cells: insights from experimentally-informed mathematical modelling
Luis Almeida, Jérôme Denis, Nathalie Ferrand +4
Glucose is a primary energy source for cancer cells. Several lines of evidence support the idea that monocarboxylate transporters, such as MCT1, elicit metabolic reprogramming of c…
A mathematical model to study the impact of intra-tumour heterogeneity on anti-tumour CD8+ T cell immune response
Emma Leschiera, Tommaso Lorenzi, Shensi Shen +2
Intra-tumour heterogeneity (ITH) has a strong impact on the efficacy of the immune response against solid tumours. The number of sub-populations of cancer cells expressing differen…
A chemotaxis-based explanation of spheroid formation in 3D cultures of breast cancer cells
Federica Bubba, Camille Pouchol, Nathalie Ferrand +4
Three-dimensional cultures of cells are gaining popularity as an in vitro improvement over 2D Petri dishes. In many such experiments, cells have been found to organize in aggregate…