20 citations · 33 across the 4 of their papers we have counts for
5 papers
An individual-based model to explore the impact of psychological stress on immune infiltration into tumour spheroids
Emma Leschiera, Gheed Al-Hity, Melanie S. Flint +4
In recent in vitro experiments on co-culture between breast tumour spheroids and activated immune cells, it was observed that the introduction of the stress hormone cortisol result…
Evolutionary dynamics of glucose-deprived cancer cells: insights from experimentally-informed mathematical modelling
Luis Almeida, Jérôme Denis, Nathalie Ferrand +4
Glucose is a primary energy source for cancer cells. Several lines of evidence support the idea that monocarboxylate transporters, such as MCT1, elicit metabolic reprogramming of c…
A mathematical model to study the impact of intra-tumour heterogeneity on anti-tumour CD8+ T cell immune response
Emma Leschiera, Tommaso Lorenzi, Shensi Shen +2
Intra-tumour heterogeneity (ITH) has a strong impact on the efficacy of the immune response against solid tumours. The number of sub-populations of cancer cells expressing differen…
A chemotaxis-based explanation of spheroid formation in 3D cultures of breast cancer cells
Federica Bubba, Camille Pouchol, Nathalie Ferrand +4
Three-dimensional cultures of cells are gaining popularity as an in vitro improvement over 2D Petri dishes. In many such experiments, cells have been found to organize in aggregate…
Energy and implicit discretization of the Fokker-Planck and Keller-Segel type equations
Luís Neves de Almeida, Federica Bubba, Benoît Perthame +1
The parabolic-elliptic Keller-Segel equation with sensitivity saturation, because of its pattern formation ability, is a challenge for numerical simulations. We provide two finite-…