5 papers · 1 filter
Correlation Matters! Streamlining the Sample Size Procedure with Composite Time-to-event Endpoints
Yunhan Mou, Fan Li, Denise Esserman +1
Composite endpoints are widely used in cardiovascular clinical trials to improve statistical efficiency while preserving clinical relevance. The Win Ratio (WR) measure and more gen…
Power calculation for cross-sectional stepped wedge cluster randomized trials with a time-to-event endpoint
Mary Ryan Baumann, Denise Esserman, Monica Taljaard +1
Stepped wedge cluster randomized trials (SW-CRTs) are a form of randomized trial whereby clusters are progressively transitioned from control to intervention, with the timing of tr…
Group sequential two-stage preference designs
Ruyi Liu, Fan Li, Denise Esserman +1
The two-stage preference design (TSPD) enables the inference for treatment efficacy while allowing for incorporation of patient preference to treatment. It can provide unbiased est…
Bayesian pathway analysis over brain network mediators for survival data
Xinyuan Tian, Fan Li, Li Shen +2
Technological advancements in noninvasive imaging facilitate the construction of whole brain interconnected networks, known as brain connectivity. Existing approaches to analyze br…
Estimation of ascertainment bias and its effect on power in clinical trials with time-to-event outcomes
E. J. Greene, P. Peduzzi, J. Dziura +4
While the gold standard for clinical trials is to blind all parties -- participants, researchers, and evaluators -- to treatment assignment, this is not always a possibility. When…