18 citations · 41 across the 10 of their papers we have counts for
10 papers
Oxygenation and spatial heterogeneity shape radiotherapy protocol ranking through phenotypic adaptation
Francesco Albanese, Giulia Chiari, Marcello Edoardo Delitala
Tumor response to radiotherapy is strongly influenced by oxygen availability and phenotypic heterogeneity, yet their combined impact on the relative performance of fractionation sc…
The role of viral dynamics and infectivity in models of oncolytic virotherapy for tumours with different motility
David Morselli, Federico Frascoli, Marcello Edoardo Delitala
The use of ad-hoc engineered viruses in the fight against tumours is one of the greatest ideas in cancer therapeutics within the last three decades. Together with other strategies…
A phenotype-structured mathematical model for the influence of hypoxia on oncolytic virotherapy
David Morselli, Giulia Chiari, Federico Frascoli +1
The effectiveness of oncolytic virotherapy is significantly affected by several elements of the tumour microenvironment, which reduce the ability of the virus to infect cancer cell…
Multi-scale modeling of Snail-mediated response to hypoxia in tumor progression
Giulia Chiari, Martina Conte, Marcello Delitala
Tumor cell migration within the microenvironment is a crucial aspect for cancer progression and, in this context, hypoxia has a significant role. An inadequate oxygen supply acts a…
A hybrid discrete-continuum modelling approach for the interactions of the immune system with oncolytic viral infections
David Morselli, Marcello E. Delitala, Adrianne L. Jenner +1
Oncolytic virotherapy, utilizing genetically modified viruses to combat cancer and trigger anti-cancer immune responses, has garnered significant attention in recent years. In our…
Hypoxia-related radiotherapy resistance in tumours: treatment efficacy investigation in an eco-evolutionary perspective
Giulia Chiari, Giada Fiandaca, Marcello Edoardo Delitala
In the study of therapeutic strategies for the treatment of cancer, eco-evolutionary dynamics are of particular interest, since characteristics of the tumour population, interactio…
Hypoxia-resistance heterogeneity in tumours: the impact of geometrical characterization of environmental niches and evolutionary trade-offs. A mathematical approach
Giulia Chiari, Giada Fiandaca, Marcello Edoardo Delitala
In the study of cancer evolution and therapeutic strategies, scientific evidence shows that a key dynamics lies in the tumor-environment interaction. In particular, oxygen concentr…
Agent-based and continuum models for spatial dynamics of infection by oncolytic viruses
David Morselli, Marcello Edoardo Delitala, Federico Frascoli
The use of oncolytic viruses as cancer treatment has received considerable attention in recent years, however the spatial dynamics of this viral infection is still poorly understoo…
Effects of mutations and immunogenicity on outcomes of anti-cancer therapies for secondary lesions
Elena Piretto, Marcello Delitala, Peter S. Kim +1
Cancer development is driven by mutations and selective forces, including the action of the immune system and interspecific competition. When administered to patients, anti-cancer…
A mathematical study of the influence of hypoxia and acidity on the evolutionary dynamics of cancer
Giada Fiandaca, Marcello Delitala, Tommaso Lorenzi
Hypoxia and acidity act as environmental stressors promoting selection for cancer cells with a more aggressive phenotype. As a result, a deeper theoretical understanding of the spa…