123 citations · 137 across the 5 of their papers we have counts for
4 papers · 1 filter
Modelling realistic 3D deformations of simple epithelia in dynamic homeostasis
Domenic P. J. Germano, Stuart T. Johnston, Edmund J. Crampin +1
The maintenance of tissue and organ structures during dynamic homeostasis is often not well understood. In order for a system to be stable, cell renewal, cell migration and cell de…
Multiscale modelling of desquamation in the interfollicular epidermis
Claire Miller, Edmund Crampin, James Osborne
Maintenance of epidermal thickness is critical to the barrier function of the skin. Decreased tissue thickness, specifically in the stratum corneum (the outermost layer of the tiss…
A mathematical model of cell fate selection on a dynamic tissue
Domenic P. J. Germano, James M. Osborne
Multicellular tissues are the building blocks of many biological systems and organs. These tissues are not static, but dynamically change over time. Even if the overall structure r…
Maintaining the stem cell niche in multicellular models of epithelia
Claire Miller, Edmund Crampin, James Osborne
The maintenance of the proliferative cell niche is critical to epithelial tissue morphology and function. In this paper we investigate how current modelling methods can result in t…