123 citations · 137 across the 5 of their papers we have counts for
6 papers
Modelling realistic 3D deformations of simple epithelia in dynamic homeostasis
Domenic P. J. Germano, Stuart T. Johnston, Edmund J. Crampin +1
The maintenance of tissue and organ structures during dynamic homeostasis is often not well understood. In order for a system to be stable, cell renewal, cell migration and cell de…
Multiscale modelling of desquamation in the interfollicular epidermis
Claire Miller, Edmund Crampin, James Osborne
Maintenance of epidermal thickness is critical to the barrier function of the skin. Decreased tissue thickness, specifically in the stratum corneum (the outermost layer of the tiss…
A simple history dependent remeshing technique to increase finite element model stability in elastic surface deformations
Jessica R. Crawshaw, Jennifer A. Flegg, James M. Osborne
In this paper, we present and validate a simple adaptive surface remeshing technique to transfer history dependent variables from an old distorting mesh to a new mesh during finite…
A mathematical model of cell fate selection on a dynamic tissue
Domenic P. J. Germano, James M. Osborne
Multicellular tissues are the building blocks of many biological systems and organs. These tissues are not static, but dynamically change over time. Even if the overall structure r…
Maintaining the stem cell niche in multicellular models of epithelia
Claire Miller, Edmund Crampin, James Osborne
The maintenance of the proliferative cell niche is critical to epithelial tissue morphology and function. In this paper we investigate how current modelling methods can result in t…
The Role of the Hes1 Crosstalk Hub in Notch-Wnt Interactions of the Intestinal Crypt
Sophie K. Kay, Heather A. Harrington, Sarah Shepherd +5
The Notch pathway plays a vital role in determining whether cells in the intestinal epithelium adopt a secretory or an absorptive phenotype. Cell fate specification is coordinated…