68 citations · 117 across the 16 of their papers we have counts for
6 papers · 1 filter
Thermodynamic cost-controllability tradeoff in metabolic currency coupling
Jumpei F. Yamagishi, Tetsuhiro S. Hatakeyama
Cellular metabolism is globally regulated by various currency metabolites such as ATP, GTP, and NAD(P)H. These metabolites cycle between charged (high-energy) and uncharged (low-en…
Enzyme as Maxwell's Demon: Steady-state Deviation from Chemical Equilibrium by Enhanced Enzyme Diffusion
Shunsuke Ichii, Tetsuhiro S. Hatakeyama, Kunihiko Kaneko
Enhanced enzyme diffusion (EED), in which the diffusion coefficient of an enzyme transiently increases during catalysis, has been extensively reported experimentally. We numericall…
Active thermodynamic force driven mitochondrial alignment
Masashi K. Kajita, Yoshiyuki Konishi, Tetsuhiro S. Hatakeyama
Mitochondria are critical organelles in eukaryotes that produce the energy currency ATP. In nerve axons, mitochondria are known to align at almost regular intervals to maintain a c…
Dynamical-systems theory of cellular reprogramming
Yuuki Matsushita, Tetsuhiro S. Hatakeyama, Kunihiko Kaneko
In cellular reprogramming, almost all epigenetic memories of differentiated cells are erased by the overexpression of few genes, regaining pluripotency, potentiality for differenti…
A Linear Reciprocal Relationship Between Robustness and Plasticity in Homeostatic Biological Networks
Tetsuhiro S. Hatakeyama, Kunihiko Kaneko
In physics of living systems, a search for relationships of a few macroscopic variables that emerge from many microscopic elements is a central issue. We evolved gene regulatory ne…
Transition in relaxation paths in allosteric molecules: enzymatic kinetically constrained model
Tetsuhiro S. Hatakeyama, Kunihiko Kaneko
A hierarchy of timescales is ubiquitous in biological systems, where enzymatic reactions play an important role because they can hasten the relaxation to equilibrium. We introduced…