3 papers
physics.bio-ph2021
Dynamical-systems theory of cellular reprogramming
Yuuki Matsushita, Tetsuhiro S. Hatakeyama, Kunihiko Kaneko
In cellular reprogramming, almost all epigenetic memories of differentiated cells are erased by the overexpression of few genes, regaining pluripotency, potentiality for differenti…
physics.bio-ph2020
A Linear Reciprocal Relationship Between Robustness and Plasticity in Homeostatic Biological Networks
Tetsuhiro S. Hatakeyama, Kunihiko Kaneko
In physics of living systems, a search for relationships of a few macroscopic variables that emerge from many microscopic elements is a central issue. We evolved gene regulatory ne…
physics.bio-ph2018
Transition in relaxation paths in allosteric molecules: enzymatic kinetically constrained model
Tetsuhiro S. Hatakeyama, Kunihiko Kaneko
A hierarchy of timescales is ubiquitous in biological systems, where enzymatic reactions play an important role because they can hasten the relaxation to equilibrium. We introduced…