227 citations · 547 across the 14 of their papers we have counts for
8 papers · 1 filter
Emergent predictability in microbial ecosystems
Jacob Moran, Lucas C. Graham, Mikhail Tikhonov
Microbial ecosystems exhibit a surprising amount of functionally relevant diversity at all levels of taxonomic resolution, presenting a significant challenge for most modeling fram…
Energy-ordered resource stratification as an agnostic signature of life
Akshit Goyal, Mikhail Tikhonov
The search for extraterrestrial life hinges on identifying biosignatures, often focusing on gaseous metabolic byproducts as indicators. However, most such biosignatures require ass…
Global epistasis on fitness landscapes
Juan Diaz-Colunga, Abigail Skwara, Karna Gowda +4
Epistatic interactions between mutations add substantial complexity to adaptive landscapes, and are often thought of as detrimental to our ability to predict evolution. Yet, patter…
Improve it or lose it: evolvability costs of competition for expression
Jacob Moran, Devon Finlay, Mikhail Tikhonov
Expression level is known to be a strong determinant of a protein's rate of evolution. But the converse can also be true: evolutionary dynamics can affect expression levels of prot…
Innovation rather than improvement: a solvable high-dimensional model highlights the limitations of scalar fitness
Mikhail Tikhonov, Remi Monasson
Much of our understanding of ecological and evolutionary mechanisms derives from analysis of low-dimensional models: with few interacting species, or few axes defining "fitness". I…
A collective phase in resource competition in a highly diverse ecosystem
Mikhail Tikhonov, Remi Monasson
Organisms shape their own environment, which in turn affects their survival. This feedback becomes especially important for communities containing a large number of species; howeve…
Community-level cohesion without cooperation
Mikhail Tikhonov
Recent work draws attention to community-community encounters ("coalescence") as likely an important factor shaping natural ecosystems. This work builds on MacArthur's classic mode…
Theoretical ecology without species
Mikhail Tikhonov
Ecosystems are commonly conceptualized as networks of interacting species. However, partitioning natural diversity of organisms into discrete units is notoriously problematic, and…