5 citations · 5 across the 3 of their papers we have counts for
4 papers
Generalized end-product feedback circuit senses high dimensional environmental fluctuations
Fang Yu, Mikhail Tikhonov
Understanding computational capabilities of simple biological circuits, such as the regulatory circuits of single-cell organisms, remains an active area of research. Recent theoret…
Global epistasis on fitness landscapes
Juan Diaz-Colunga, Abigail Skwara, Karna Gowda +4
Epistatic interactions between mutations add substantial complexity to adaptive landscapes, and are often thought of as detrimental to our ability to predict evolution. Yet, patter…
A simple regulatory architecture allows learning the statistical structure of a changing environment
Stefan Landmann, Caroline M. Holmes, Mikhail Tikhonov
Bacteria live in environments that are continuously fluctuating and changing. Exploiting any predictability of such fluctuations can lead to an increased fitness. On longer timesca…
Improve it or lose it: evolvability costs of competition for expression
Jacob Moran, Devon Finlay, Mikhail Tikhonov
Expression level is known to be a strong determinant of a protein's rate of evolution. But the converse can also be true: evolutionary dynamics can affect expression levels of prot…