3 papers
stat.ME2026
Global testing of SNP-methylation interactions on binary phenotypes via a logistic functional regression model
Yvelin Gansou, Karim Oualkacha, Marzia Angela Cremona +1
Understanding how genetic and epigenetic factors jointly influence binary health outcomes remains a major challenge in biomedical research. We propose a global test for the overall…
stat.ME2025
A Functional Approach to Testing Overall Effect of Interaction Between DNA Methylation and SNPs
Yvelin Gansou, Karim Oualkacha, Marzia Angela Cremona +1
We introduce a test for the overall effect of interaction between DNA methylation and a set of single nucleotide polymorphisms (SNPs) on a quantitative phenotype. The developed inf…
stat.ME2021
Detecting differentially methylated regions in bisulfite sequencing data using quasi-binomial mixed models with smooth covariate effect estimates
Kaiqiong Zhao, Karim Oualkacha, Lajmi Lakhal-Chaieb +6
Identifying disease-associated changes in DNA methylation can help to gain a better understanding of disease etiology. Bisulfite sequencing technology allows the generation of meth…