3 papers
q-bio.GN2021
COSINE: A Web Server for Clonal and Subclonal Structure Inference and Evolution in Cancer Genomics
Xiguo Yuan, Yuan Zhao, Yang Guo +10
Cancers evolve from mutation of a single cell with sequential clonal and subclonal expansion of somatic mutation acquisition. Inferring clonal and subclonal structures from bulk or…
q-bio.GN2012
Integrating Prior Knowledge Into Prognostic Biomarker Discovery based on Network Structure
Yupeng Cun, Holger Fröhlich
Background: Predictive, stable and interpretable gene signatures are generally seen as an important step towards a better personalized medicine. During the last decade various meth…
q-bio.PE2010
On the Evolutionary Fate of Mutant Allele at Duplicate Loci: a Theoretical and Simulation Study
Yupeng Cun
Gene duplications are one of major primary driving forces for evolutionary novelty. We took population genetics models of genes duplicate to study how evolutionary forces acting du…