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q-bio.SC2026
Amplifying gene expression sensitivity by surface condensation on DNA
Tarek Tohme, Henry Alston, Jacqueline Janssen +2
Condensation of proteins on DNA is a central aspect of genome organisation, and has been proposed as a mechanism of gene regulation in eukaryotes, notably by mediating the action o…
q-bio.PE2026
Neutralization titers reveal the structure of polyclonal antibody responses
Henry Alston, Thierry Mora, Aleksandra M. Walczak
The composition of a polyclonal antibody response is hard to measure experimentally but contains vital information about the robustness of immunity. Here, we argue that the statist…
q-bio.PE2026
Modeling Protein Evolution via Generative Inference From Monte Carlo Chains to Population Genetics
Leonardo Di Bari, Thierry Mora, Andrea Pagnani +3
Generative models derived from large protein sequence alignments define complex fitness landscapes, but their utility for accurately modeling non-equilibrium evolutionary dynamics…