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q-bio.BM2024
Energy-based generative models for monoclonal antibodies
Paul Pereira, Hervé Minoux, Aleksandra M. Walczak +1
Since the approval of the first antibody drug in 1986, a total of 162 antibodies have been approved for a wide range of therapeutic areas, including cancer, autoimmune, infectious,…
q-bio.CB2024
Single cells can resolve graded stimuli
Mirna Kramar, Lauritz Hahn, Aleksandra M Walczak +2
Cells use signalling pathways as windows into the environment to gather information, transduce it into their interior, and use it to drive behaviours. MAPK (ERK) is a highly conser…
q-bio.PE2024
How host mobility patterns shape antigenic escape during viral-immune co-evolution
Natalie Blot, Caelan Brooks, Daniel W. Swartz +6
Viruses like influenza have long coevolved with host immune systems, gradually shaping the evolutionary trajectory of these pathogens. Host immune systems develop immunity against…