216 citations · 1.7k across the 29 of their papers we have counts for
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A versatile multicomponent mesoporous silica nanosystem with dual antimicrobial and osteogenic effects
Elena Alvarez, Manuel Estevez, Carla Jimenez-Jimenez +4
In this manuscript, we propose a simple and versatile methodology to design nanosystems based on biocompatible and multicomponent mesoporous silica nanoparticles (MSNs) for infecti…
Effective reduction of biofilm through photothermal therapy by gold core@shell based mesoporous silica nanoparticles
Ana Garcia, Blanca Gonzalez, Catherine Harvey +2
Bacterial biofilms can initiate chronic infections that become difficult to eradicate. There is an unmet need for effective therapeutic strategies that control and inhibit the grow…
Response of RAW 264.7 and J774A.1 macrophages to particles and nanoparticles of a mesoporous bioactive glass: A comparative study"
M. J. Feito, L. Casarrubios, M. Onaderra +6
Mesoporous bioactive glasses (MBGs) are bioceramics designed to induce bone tissue regeneration and very useful materials with the ability to act as drug delivery systems. MBGs can…
Cerium (III) and (IV) containing mesoporous glasses/alginate beads for bone regeneration: bioactivity, biocompatibility and reactive oxygen species activity
E. Varini, S. Sanchez-Salcedo, G. Malavasi +3
A very small number of biomaterials investigated for bone regeneration was reported as able to prevent the oxidative stress. In this study beads based on alginate hydrogel and meso…
Novel ion-doped mesoporous glasses for bone tissue engineering: Study of their strctural characteristics influenced by the presence of phosphorous oxide
A Philippart, N Gomez-Cerezo, D Arcos +4
Ion-doped binary SiO2-CaO and ternary SiO2-CaO-P2O5 mesoporous bioactive glasses were synthesised and characterised to evaluate the influence of P2O5 in the glass network structure…
Mesoporous core-shell silica nanoparticles with anti-fouling properties for ovarian cancer therapy
Sandra Sanchez-Salcedo, Maria Vallet-Regi, Sophia Allaf Shanin +2
Mesoporous silica nanoparticles (MSNPs) have many potential applications in biomedical fields. However, when MSNPs are exposed to plasma, protein adsorption leads to opsonization a…
Strontium-releasing mesoporous bioactive glasses with anti-adhesive zwitterionic surface as advanced biomaterials for bone tissue regeneration
Carlotta Pontremoli, Isabel Izquierdo-Barba, Giorgia Montalbano +3
Hypothesis The treatment of bone fractures still represents a challenging clinical issue when complications due to impaired bone remodelling (i.e. osteoporosis) or infections occur…
Prevention of bacterial adhesion to zwitterionic biocompatible mesoporous glasses
S Sanchez-Salcedo, A Garcia, M Vallet-Regi
Novel materials, based on Mesoporous Bioactive Glasses (MBGs) in the ternary system SiO2-CaO-P2O5, decorated with (3-aminopropyl)triethoxysilane (APTES) and subsequently with amino…
Induction of VEGF secretion from bone marrow stromal cell line (ST-2) by the dissolution products of mesoporous silica glass particles containing CuO and SrO
Preethi Balasubramanian, Antonio J. Salinas, Sandra Sanchez-Salcedo +3
Certain biomaterials are capable of inducing the secretion of Vascular Endothelial Growth Factor (VEGF) from cells exposed to their biochemical influence, which plays a vital role…
Self-immolative chemistry in nanomedicine
M Gisbert-Garzaran, M Manzano, M Vallet-Regi
Self-Immolative Chemistry is based on the cascade of disassembling reactions triggered by the adequate stimulation and leading to the sequential release of the smaller constituent…
Mixed-charge pseudo-zwitterionic mesoporous silica nanoparticles with lowfouling and reduced cell uptake properties
Noemi Encinas, Mercedes Angulo, Carlos Astorga +3
The design of drug delivery systems needs to consider biocompatibility and host body recognition for an adequate actuation. In this work, mesoporous silica nanoparticles (MSNs) sur…
Mesoporous Silica Nanoparticles Decorated with Polycationic Dendrimers for Infection Treatment
Blanca Gonzalez, Montserrat Colilla, Jaime Diez +4
This work aims to provide an effective and novel solution for the treatment of infection by using nanovehicles loaded with antibiotics capable of penetrating the bacterial wall, th…
Multiscale porosity in mesoporous bioglass 3D-printed scaffolds for bone regeneration
M. Natividad Gomez-Cerezo, Juan Pena, Saso Ivanovski +3
In order to increase the bone forming ability of MBG-PCL composite scaffold, microporosity was created in the struts of 3D-printed MBG-PCL scaffolds for the manufacturing of a cons…
Effects of mesoporous SiO2-CaO nanospheres on the murine peritoneal macrophages -- Candida albicans interface
R. Diez-Orejas, L. Casarrubios, M. J. Feito +4
The use of nanoparticles for intracellular drug delivery could reduce the toxicity and side effects of the drug but, the uptake of these nanocarriers could induce adverse effects o…
Metabolomic response of osteosarcoma cells to nanographene oxide-mediated hyperthermia
Monica Cicuendez, Joana Flores, Helena Oliveira +4
Nanographene oxide (nGO)-mediated hyperthermia has been increasingly investigated as a localised, minimally invasive anticancer therapeutic approach. Near InfraRed (NIR) light irra…
The effect of biomimetic mineralization of 3D-printed mesoporous bioglass scaffolds on physical properties and in vitro osteogenicity
M. Natividad Gomez-Cerezo, Daniel Lozano, Daniel Arcos +2
Three-dimensional Mesoporous bioactive glasses (MBGs) scaffolds has been widely considered for bone regeneration purposes and additive manufacturing enables the fabrication of high…
Lectin-conjugated pH-responsive mesoporous silica nanoparticles for targeted bone cancer treatment
M. Martinez-Carmona, D. Lozano, M. Colilla +1
A novel multifunctional nanodevice based in doxorubicin (DOX)- loaded mesoporous silica nanoparticles (MSNs) as nanoplatforms for the assembly of different building blocks has been…
Molecular gates in mesoporous bioactive glasses for the treatment of bone tumors and infection
L Polo, N Gomez-Cerezo, E Aznar +5
Silica mesoporous nanomaterials have been proved to have meaningful application in biotechnology and biomedicine. Particularly, mesoporous bioactive glasses are recently gaining im…
Collagenase Nanocapsules: An Approach to Fibrosis Treatment
MR Villegas, A Baeza, A Usategui +3
Fibrosis is a common lesion in different pathologic diseases and is defined by the excessive accumulation of collagen. Different approaches have been used to treat different condit…
Suicide-Gene Transfection of Tumor-tropic Placental Stem Cells employing Ultrasound-Responsive Nanoparticles
Juan L. Paris, Paz de la Torre, M. Victoria Cabanas +3
A Trojan-horse strategy for cancer therapy employing tumor-tropic mesenchymal stem cells transfected with a non-viral nanovector is here presented. In this sense, ultrasound-respon…
Incorporation and effects of mesoporous SiO2-CaO nanospheres loaded with ipriflavone on osteoblast/osteoclast cocultures
Laura Casarrubios, Natividad Gomez-Cerezo, Maria Jose Feito +3
Mesoporous nanospheres in the system SiO2-CaO (NanoMBGs) with a hollow core surrounded by a radial arrangement of mesopores were characterized, labeled with FITC (FITC-NanoMBGs) an…
Effects of a mesoporous bioactive glass on osteoblasts, osteoclasts and macrophages
N. Gomez-Cerezo, L. Casarrubios, I. Morales +4
A mesoporous bioactive glass (MBG) of molar composition 75SiO2-20CaO-5P2O5 (MBG-75S) has been synthetized as a potential bioceramic for bone regeneration purposes. X-ray diffractio…
Concanavalin A-targeted mesoporous silica nanoparticles for infection treatment
Marina Martinez-Carmona, Isabel Izquierdo-Barba, Montserrat Colilla +1
The ability of bacteria to form biofilms hinders any conventional treatment against chronic infections and has serious socio-economic implications. In this sense, a nanocarrier cap…
3D scaffold with effective multidrug sequential release against bacteria biofilm
Rafaela Garcia-Alvarez, Isabel Izquierdo-Barba, Maria Vallet-Regi
Bone infection is a feared complication following surgery or trauma that remains as an extremely difficult disease to deal with. So far, the outcome of therapy could be improved wi…