Concanavalin A-targeted mesoporous silica nanoparticles for infection treatment

Abstract

The ability of bacteria to form biofilms hinders any conventional treatment against chronic infections and has serious socio-economic implications. In this sense, a nanocarrier capable of overcoming the barrier of the mucopolysaccharide matrix of the biofilm and releasing its loaded-antibiotic within would be desirable. Herein, a new nanosystem based on levofloxacin (LEVO)-loaded mesoporous silica nanoparticles (MSNs) decorated with lectin Concanavalin A (ConA) has been developed. The presence of ConA promotes its internalization into the biofilm matrix, which increases the antimicrobial efficacy of the antibiotic hosted within the mesopores. This nanodevice is envisioned as a promising alternative to conventional infection treatments by improving the antimicrobial efficacy and reducing side effects.

27 pages, 9 figures

References in corpus (3)

• Lectin-conjugated pH-responsive mesoporous silica nanoparticles for targeted bone cancer treatment
• Mesoporous Silica Nanoparticles Decorated with Polycationic Dendrimers for Infection Treatment
• Multifunctional pH sensitive 3D scaffolds for treatment and prevention of bone infection

Cited by in corpus (3)

• Effective reduction of biofilm through photothermal therapy by gold core@shell based mesoporous silica nanoparticles
• Impact of the antibiotic-cargo from MSNs on Gram-positive and Gram-negative bacterial biofilms
• A versatile multicomponent mesoporous silica nanosystem with dual antimicrobial and osteogenic effects