215 citations · 240 across the 5 of their papers we have counts for
5 papers
Cooperativity and Stability in a Langevin Model of Protein Folding
Gabriel F. Berriz, Alexander M. Gutin, Eugene I. Shakhnovich
We present two simplified models of protein dynamics based on Langevin's equation of motion in a viscous medium. We explore the effect of the potential energy function's symmetry o…
Theory of Kinetic Partitioning in Protein Folding (With Application to Prions)
V. I. Abkevich, A. M. Gutin, E. I. Shakhnovich
In this paper we study the phenomenon of kinetic partitioning when a polypeptide chain has two ground state conformations one of which is more kinetically reachable than the other.…
Chain length scaling of protein folding time
A. M. Gutin, V. I. Abkevich, E. I. Shakhnovich
Folding of protein-like heteropolymers into unique 3D structures is investigated using Monte Carlo simulations on a cubic lattice. We found that folding time of chains of length $N…
Cooperativity of Protein Folding and the Random-Field Ising Model
A. M. Gutin, V. I. Abkevich, E. I. Shakhnovich
The relation between cooperativity of protein folding and the Random-Field Ising Model (RFIM) is established. Generalization of the Imry-Ma argument predicts cooperative folding tr…
Statistical mechanics of a cross-linked polymer blend
C. D. Sfatos, A. M. Gutin, E. I. Shakhnovich
We study a blend of two kinds of homopolymers with tendency for segragation. Cross-links between the chains of different kinds do not allow macrophase separation. Instead microphas…